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Spirocyclic nonpeptide glycoprotein IIb-IIIa antagonists. Part 1: design of potent and specific
M S Smyth1, J Rose, M M Mehrotra
1COR Therapeutics, Inc, Department of Medicinal Chemistry and Biology, South San Francisco, CA 94080, USA.
Bioorganic & Medicinal Chemistry Letters
|June 8, 2001
Abstract:
The synthesis and biological activity of novel glycoprotein IIb-IIla antagonists containing the 3,9-diazaspiro[5.5]undecane nucleus are described. The potent activity of these compounds as platelet aggregation inhibitors demonstrates the utility of the spirocyclic structures as a central template for nonpeptide RGD mimics.