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Malakoplakia of bone. A case report.

M Choudhury1, P Bajaj, R Jain

  • 1Departments of Pathology and Paediatrics, Lady Hardinge Medical College and Kalawati Saran Children's Hospital, New Delhi, India.

Acta Cytologica
|June 8, 2001
PubMed
Summary

Malakoplakia, a rare granulomatous disease, involves histiocytes with Michaelis-Gutmann bodies. This case showed bone malakoplakia regression after treatment, suggesting cytology may aid diagnosis.

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Area of Science:

  • Pathology
  • Granulomatous Diseases
  • Histiocytic Disorders

Background:

  • Malakoplakia is a rare granulomatous condition.
  • Characterized by histiocytes (Von Hansemann cells) with Michaelis-Gutmann bodies.
  • Distinctive intracytoplasmic, laminated inclusions.

Observation:

  • A 3-year-old male presented with a month-long gluteal swelling.
  • Fine needle aspirate smears revealed characteristic histiocytes.
  • Intracytoplasmic, basophilic, laminated, targetoid Michaelis-Gutmann bodies were observed.

Findings:

  • Histopathology confirmed malakoplakia of bone.
  • The lesion demonstrated regression following therapy.
  • Cytologic features were diagnostic of malakoplakia.

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Implications:

  • Characteristic cytologic features and Von Hansemann cells may be diagnostic.
  • Potential to obviate the need for bone biopsy in diagnosing malakoplakia.
  • Highlights the importance of cytologic examination in rare diseases.