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A normative reference database study for Pronosco X-posure System.

D M Black1, L Palermo, T Sørensen

  • 1University of California, San Francisco, CA 94106, USA. Dblack@psg.ucsf.edu

Journal of Clinical Densitometry : the Official Journal of the International Society for Clinical Densitometry
|June 8, 2001
PubMed
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The Pronosco X-posure System estimates bone mineral density (BMD) from hand radiographs. This radiogrammetry method shows strong correlation with dual X-ray absorptiometry (DXA) at the wrist, suggesting it as a potential osteoporosis screening tool.

Area of Science:

  • Radiology
  • Osteoporosis Research
  • Medical Imaging Analysis

Background:

  • Radiogrammetry, using cortical width from radiographs, has been utilized for bone strength estimation for over 40 years.
  • Advances in computing and automated image analysis have recently renewed interest in radiogrammetry techniques.
  • The Pronosco X-posure System is a novel device designed to estimate bone mineral density (BMD) using forearm and hand radiographs.

Purpose of the Study:

  • To establish reference ranges for BMD measurements obtained with the Pronosco X-posure System (DXR-BMD).
  • To compare DXR-BMD measurements with dual X-ray absorptiometry (DXA) at the wrist and hip.
  • To evaluate the utility of the X-posure System as an alternative method for osteoporosis assessment.

Main Methods:

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  • Hand and forearm radiographs were acquired from 832 women (ages 20-79) across four US clinical centers.
  • Dual X-ray absorptiometry (DXA) was performed at the wrist and hip for comparative analysis.
  • The Pronosco X-posure System was used to estimate bone mineral density (DXR-BMD) from the radiographs.

    • Main Results:

    • The peak DXR-BMD was estimated to occur at age 38, with a mean of 0.598 g/cm² (SD = 0.034 g/cm²).
    • A strong correlation (0.90) was observed between DXR-BMD and DXA at the wrist.
    • Correlation between DXR-BMD and DXA at the hip was 0.61, and the relationship to fracture history was comparable to DXA.

    Conclusions:

    • The Pronosco X-posure System demonstrates a high correlation with DXA at the wrist, indicating its potential as a viable alternative for osteoporosis assessment.
    • The system provides reliable BMD estimates from hand radiographs, supporting its use in clinical settings.
    • Further validation may establish the X-posure System as a valuable tool for widespread osteoporosis screening and management.