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Antiplatelet activity of N-methoxycarbonyl aporphines from Rollinia mucosa
1Graduate Institut of Natural Products, Kaohsiung Medical University, Kaohsiung, Taiwan.
Phytochemistry
|June 8, 2001
Abstract:
Bioassay-directed fractionation of the stems of Rollinia mucosa led to the isolation of new N-methoxycarbonyl aporphine alkaloids, romucosine A (1), romucosine B (2), romucosine C (3), and romucosine D (4), along with the known alkaloid, N-methoxylcarbonyl-nornuciferine (5). Alkaloids 1 and 4 exhibited significant inhibition of collagen, arachidonic acid, and platelet activating factor-induced platelet aggregation, and alkaloid 3 also showed an inhibitory effect on arachidonic acid induced platelet aggregation.