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Helicobacter pylori infection in children with constitutional delay of growth and puberty

A Büyükgebiz1, B Dündar, E Böber

  • 1Department of Pediatric Endocrinology, Dokuz Eylül University Faculty of Medicine, Izmir, Turkey. atillabuyukgebiz@deu.edu.tr

Journal of Pediatric Endocrinology & Metabolism : JPEM
|June 8, 2001
PubMed

Insights

Helicobacter pylori infection is more common in children with constitutional delay of growth and puberty (CDGP). This suggests H. pylori may contribute to growth and pubertal delays in pediatric patients.

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Gastroenterology

Background:

  • Helicobacter pylori is a common gastroduodenal pathogen linked to gastritis and ulcers.
  • H. pylori infection is hypothesized to be a potential cause of growth retardation in children.
  • Constitutional delay of growth and puberty (CDGP) affects children's physical development.

Purpose of the Study:

  • To investigate the seroprevalence of H. pylori in children diagnosed with CDGP.
  • To compare H. pylori infection rates between children with CDGP and healthy controls.

Main Methods:

  • Serological testing for H. pylori IgG antibodies was performed.
  • The study included 24 children with CDGP and 32 age-matched healthy controls.
  • Statistical analysis was used to compare infection rates between groups.

Main Results:

  • H. pylori IgG positivity was found in 66.6% of children with CDGP.
  • In the control group, 37.5% tested positive for H. pylori IgG.
  • A significantly higher prevalence of H. pylori was observed in children with CDGP (p <0.05).

Conclusions:

  • The study supports the hypothesis that H. pylori infection may be an environmental factor contributing to CDGP.
  • Findings suggest a potential link between H. pylori and delayed growth and puberty in children.
  • Further research is warranted to elucidate the role of H. pylori in pediatric growth disorders.

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