Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hematopoietic stem cells.

E Gunsilius1, G Gastl, A L Petzer

  • 1Department of Hematology & Oncology, University Hospital, Innsbruck, Austria. eberhard.gunsilius@uibk.ac.at

Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie
|June 8, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Long enduring response on teclistamab in a patient with myeloma relapse after allogeneic hematopoietic stem cell transplantation - a case report.

Annals of hematology·2026
Same author

Early autologous and/or allogeneic stem cell transplantation for adult patients with advanced stage T- lymphoblastic leukemia/lymphoma or Burkitt lymphoma. A retrospective single-centre analysis.

Annals of hematology·2024
Same author

Early autologous and allogeneic peripheral blood stem cell transplantation for adult patients with acute B and T cell precursor neoplasms: a 12-year single center experience.

Annals of hematology·2021
Same author

Real world analysis of high-cut-off (HCO) hemodialysis with bortezomib-based backbone therapy in patients with multiple myeloma and acute kidney injury.

Journal of nephrology·2020
Same author

Autologous stem cell transplantation following simultaneous liver and kidney transplantation in severe amyloid light chain amyloidosis associated with multiple myeloma: a case report.

Journal of medical case reports·2020
Same author

Levels of CEACAM6 in Peripheral Blood Are Elevated in Patients with Plasma Cell Disorders: A Potential New Diagnostic Marker and a New Therapeutic Target?

Disease markers·2019
Same journal

Tumor microenvironment-mediated interactions between macrophages and cancer cells define immunoregulatory transcriptional programs.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie·2026
Same journal

Photocontrol of zebrafish behavior with a photoswitchable ligand of nicotinic acetylcholine receptors.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie·2026
Same journal

Corrigendum to "Ruyiping extract reduces lung metastasis in triple negative breast cancer by regulating macrophage polarization" [Biomed. Pharmacother. 141 (2021) 111883].

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie·2026
Same journal

Microfluidic human liver slices reveal antifibrotic effects of liraglutide via HSC deactivation and ECM remodeling.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie·2026
Same journal

Corrigendum to "Targeting PD-L1 and disrupting Siglec-9 cooperatively potentiate macrophage phagocytosis of breast cancer via a trispecific macrophage engager (TriME)" [Biomed. Pharmacother. 200 (2026), 119609].

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie·2026
Same journal

Targeted attenuation of liver fibrosis using microbubble-enhanced protease-activated receptor 1 chimeric antigen receptor T cells.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie·2026
See all related articles

Hematopoietic stem cells (HSCs) in bone marrow produce blood cells and can restore the hematopoietic system. Mobilizing HSCs into peripheral blood allows for easier clinical transplantation.

Area of Science:

  • Hematology
  • Stem Cell Biology
  • Developmental Biology

Background:

  • Hematopoietic stem cells (HSCs) are crucial for lifelong blood cell production, residing in the bone marrow.
  • HSCs possess the unique ability to reconstitute the entire hematopoietic system, vital for treating bone marrow failure and aplasia.

Purpose of the Study:

  • This review details the developmental trajectory of the hematopoietic system from embryonic stages to adulthood.
  • It also covers the characterization, enumeration, purification, and ex vivo expansion of HSCs for clinical applications.

Main Methods:

  • The review synthesitsizes existing literature on HSC development and clinical applications.
  • It discusses methods for mobilizing HSCs from bone marrow to peripheral blood using hematopoietic cytokines.

Related Experiment Videos

  • Key techniques for HSC characterization, enumeration, purification, and ex vivo expansion are outlined.

    • Main Results:

    • HSCs are essential for maintaining adequate blood cell production throughout life.
    • Mobilization of HSCs into peripheral blood offers a practical method for harvesting cells for transplantation.
    • Current strategies allow for the isolation and expansion of HSCs for therapeutic purposes.

    Conclusions:

    • Understanding HSC development and function is critical for regenerative medicine.
    • Ex vivo expansion and genetic manipulation of HSCs hold promise for future therapies.
    • The identification and expansion of multipotent stem cells capable of generating non-hematopoietic tissues represent a significant future research direction.