Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Occult metastasis.

D Hawes1, A M Neville, R J Cote

  • 1Department of Pathology, Keck School of Medicine at the University of Southern Califonia/Norris Comprehensive Cancer Center, Los Angeles 90033, USA.

Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie
|June 8, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Machine Learning Classification of Alzheimer's Disease Pathology Reveals Diffuse Amyloid as a Major Predictor of Cognitive Impairment in Human Hippocampal Subregions.

bioRxiv : the preprint server for biology·2023
Same author

Pediatric Atypical Teratoid/Rhabdoid Tumors of the Brain: Identification of Metabolic Subgroups Using In Vivo <sup>1</sup>H-MR Spectroscopy.

AJNR. American journal of neuroradiology·2019
Same author

Evaluating Practitioner Training to Improve Competencies and Organizational Practices for Engaging Fathers in Parenting Interventions.

Child psychiatry and human development·2018
Same author

Mothers, Fathers, and Parental Systems: A Conceptual Model of Parental Engagement in Programmes for Child Mental Health-Connect, Attend, Participate, Enact (CAPE).

Clinical child and family psychology review·2016
Same author

Is follow-up CT imaging of the chest and abdomen necessary after preoperative neoadjuvant therapy in rectal cancer patients without evidence of metastatic disease at diagnosis?

Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland·2013
Same author

Contrast-enhanced free-breathing 3D T1-weighted gradient-echo sequence for hepatobiliary MRI in patients with breath-holding difficulties.

European radiology·2013
Same journal

Wnt activation during epileptogenesis prevents pathological immature dentate granule cell morphological changes in animal models of unilateral and bilateral temporal lobe epilepsy.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie·2026
Same journal

Protective effects of ACF210, a dual GLP-1/APJ receptor agonist, against cardiovascular-kidney-metabolic syndrome induced by T2D.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie·2026
Same journal

Tumor microenvironment-mediated interactions between macrophages and cancer cells define immunoregulatory transcriptional programs.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie·2026
Same journal

Photocontrol of zebrafish behavior with a photoswitchable ligand of nicotinic acetylcholine receptors.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie·2026
Same journal

Corrigendum to "Ruyiping extract reduces lung metastasis in triple negative breast cancer by regulating macrophage polarization" [Biomed. Pharmacother. 141 (2021) 111883].

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie·2026
Same journal

Microfluidic human liver slices reveal antifibrotic effects of liraglutide via HSC deactivation and ECM remodeling.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie·2026
See all related articles

Detecting hidden cancer spread early is crucial for patient outcomes. New methods aim to find occult metastases before they are detectable by standard evaluations, improving treatment success.

Area of Science:

  • Oncology
  • Cancer Metastasis Research
  • Diagnostic Medicine

Background:

  • Tumor spread (regional or systemic) significantly impacts invasive cancer patient outcomes.
  • Some patients develop recurrent disease despite no initial signs of systemic spread, indicating occult micrometastases.
  • Adjuvant therapies are believed to work by eliminating these undetectable metastases.

Purpose of the Study:

  • To highlight the critical need for methods detecting occult metastases in early-stage cancer.
  • To emphasize the importance of identifying disease spread before conventional clinical or pathological detection.

Main Methods:

  • Review of existing literature on cancer metastasis and detection methods.
  • Analysis of the limitations of current diagnostic evaluations (pathological, clinical, biochemical, radiological).

Related Experiment Videos

Main Results:

  • Occult systemic spread is a key factor in treatment failure for some cancer patients.
  • Current diagnostic methods are insufficient to detect minimal residual disease in all cases.
  • The development of sensitive detection methods for occult metastases is a significant research focus.

Conclusions:

  • Accurate detection of occult metastases is essential for improving cancer patient prognoses.
  • Advanced diagnostic techniques are needed to identify subclinical disease spread.
  • Early detection of micrometastases can guide more effective adjuvant therapy strategies.