Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Simultaneous multianalyte detection with a nanometer-scale pore.

J J Kasianowicz1, S E Henrickson, H H Weetall

  • 1NIST, Biotechnology Division, Gaithersburg, Maryland 20899-8313, USA. john.kasianowicz@nist.gov

Analytical Chemistry
|June 8, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Longitudinal studies on interdisciplinary teaching models incorporating plastic surgery.

Annals of the Royal College of Surgeons of England·2025
Same author

Mycobacterial lipoarabinomannan negatively interferes with macrophage responses to <i>Aspergillus fumigatus in-vitro</i>.

bioRxiv : the preprint server for biology·2024
Same author

A retrospective study of tuberculosis outcomes in Gulf Province, Papua New Guinea.

Public health action·2019
Same author

Nodal disease predicts recurrence whereas other traditional factors affect survival in a cohort of South African patients with differentiated thyroid carcinoma.

Cancers of the head & neck·2019
Same author

Catastrophic drug errors involving tranexamic acid administered during spinal anaesthesia.

Anaesthesia·2019
Same author

Requiem for Nigro or is anal squamous carcinoma still a surgical problem: Abdominoperineal excision rather than a defunctioning stoma?

South African journal of surgery. Suid-Afrikaanse tydskrif vir chirurgie·2018
Same journal

Strain-Level Food Surveillance of <i>Escherichia coli</i> Using a Specific-Nonspecific Hybrid Sensor Array Strategy.

Analytical chemistry·2026
Same journal

A Field-Portable Fe(IV)-Mediated Competitive Quenching Chemiluminescence Platform with a Synchronous Y-Shaped Flow-through Cell for Broad-Spectrum Quantification of Volatile Phenols.

Analytical chemistry·2026
Same journal

Single-Molecule Characterization of CRISPR-Cas12a for Amplification-Free Genetic Testing.

Analytical chemistry·2026
Same journal

Integrated Acoustofluidic Manipulation and Oscillation-Stabilized Magnetic Relaxation Biosensing for <i>Salmonella</i> Detection.

Analytical chemistry·2026
Same journal

A Self-Powered Sensing Platform Based on the Janus Heterostructure for Machine Learning-Assisted Dual-Mode Detection of 17β-Estradiol.

Analytical chemistry·2026
Same journal

Large Language Model-Generated Dietary Metabolite Biomarker Database Drives Deep Annotation of the Human Diet Metabolome.

Analytical chemistry·2026
See all related articles

This study introduces a novel polymer-based system for detecting analytes in solution using nanometer-scale pores. This method expands analyte detection capabilities and allows for simultaneous detection of multiple targets like proteins.

Area of Science:

  • Biotechnology
  • Nanotechnology
  • Analytical Chemistry

Background:

  • Existing methods utilize modified channels for analyte detection.
  • There is a need for simpler and broader analyte detection systems.

Purpose of the Study:

  • To demonstrate a simpler system for analyte detection using nanometer-scale pores.
  • To expand the range of detectable analytes compared to channel-based methods.

Main Methods:

  • Polymers with covalently linked recognition elements were threaded through nanometer-scale pores.
  • Analyte binding to polymers altered polymer translocation rates through the pore.
  • Signals from individual polymer translocations were analyzed for detection and quantitation.

Main Results:

Related Experiment Videos

  • The system allows for multianalyte detection and quantitation.
  • Two different proteins were simultaneously detected using this technique.

Conclusions:

  • This polymer-based nanopore system offers a simpler and more versatile approach to analyte detection.
  • The method has potential for simultaneous detection and quantification of multiple analytes in solution.