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[Problems in inducing pulmonary maturation in relation to premature delivery]
1Ustav pro péci o matku a dítĕ, Praha.
Insights
Researchers are exploring early markers for preterm birth and optimal therapies to mature fetal lungs, aiming to reduce neonatal mortality and morbidity. Investigating ambroxol with corticoids offers a potential improvement over current treatments for respiratory distress syndrome.
Area of Science:
- Neonatology
- Pulmonology
- Obstetrics
Context:
- Premature delivery poses significant risks for neonatal mortality and morbidity.
- Current therapies like corticoid monotherapy have limitations in preventing respiratory distress syndrome (RDS).
- The incidence of RDS remains high, necessitating improved strategies for fetal lung maturity.
Purpose:
- To review current strategies for inducing pulmonary maturity in preterm neonates.
- To evaluate the effectiveness of different therapeutic protocols in reducing neonatal complications.
- To discuss the potential of ambroxol in combination with corticoids for enhancing fetal lung development.
Summary:
- Efforts focus on identifying early markers for preterm birth and optimizing therapeutic protocols for fetal lung maturity.
- Corticoid monotherapy has shown some success in reducing RDS in low birth weight neonates but is insufficient.
- Ambroxol combined with corticoids is presented as a potential therapeutic approach to improve outcomes.
Impact:
- Improved therapeutic strategies can significantly reduce early neonatal mortality and morbidity.
- Effective induction of pulmonary maturity is crucial for preventing conditions like RDS, intraventricular-periventricular hemorrhage, and necrotizing enterocolitis.
- This review aims to guide clinical practice towards more effective interventions for preterm infants.
Abstract:
At presents efforts are made to find valid early markers of premature delivery and if it is inevitable to use an optimal therapeutic protocol for induction of pulmonary maturity which may lead to reduction of early neonatal mortality and morbidity (intraventricular-periventricular haemorrhage, necrotizing enterocolitis, bronchopulmonary dysplasia, air-leak syndrome, respiratory distress syndrome--RDS). Hitherto used corticoid monotherapy reduced the incidence of RDS in neonates with a birth weight lower than 1500 g but the incidence is still relatively high and RDS is still one of the main causes of death of immature neonates. Even the use of thyrotropic hormones did not reduce its incidence. Another possible therapeutic approach is ambroxol administration in combination with corticoids. In the presented review the authors discuss the problem of optimal induction of pulmonary maturity in relation to premature delivery.