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Multiple organ dysfunction syndrome: a narrative review.

D Johnson1, I Mayers

  • 1Department of Anesthesia, University of Saskatchewan, Saskatoon, Canada. cujec@v-wave.com

Canadian Journal of Anaesthesia = Journal Canadien D'Anesthesie
|June 8, 2001
PubMed
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Multiple organ dysfunction syndrome (MODS) is a leading cause of death in ICUs, often arising from unbridled inflammation after shock. Current therapies have not significantly improved outcomes for this critical condition.

Area of Science:

  • Critical Care Medicine
  • Pathophysiology
  • Translational Research

Background:

  • Multiple organ dysfunction syndrome (MODS) is the predominant cause of mortality in intensive care units (ICUs).
  • Advances in resuscitation may unmask delayed MODS, highlighting its significance after various forms of shock.
  • Uncontrolled systemic inflammation is a key factor in the development of MODS.

Purpose of the Study:

  • To review multiple organ dysfunction syndrome (MODS).
  • Focus on clinical measurement systems, molecular mechanisms, and therapeutic strategies.
  • Explore therapeutic directions informed by molecular mechanisms.

Main Methods:

  • Comprehensive literature search of Medline, Cochrane, and Best Evidence databases (1996-2000).

Related Experiment Videos

  • Inclusion of conference proceedings and bibliographies of review articles.
  • Keywords: multiple organ failure, multiple system organ dysfunction, sepsis, septic shock, shock, systemic inflammatory response syndrome.

    • Main Results:

    • MODS is the most common cause of death in ICUs.
    • MODS development is linked to shock and systemic inflammation.
    • Therapies targeting MODS have not yet dramatically altered patient outcomes.

    Conclusions:

    • MODS can serve as a critical measure of disease severity and an outcome marker for quality of care.
    • Anesthesiologists should be aware of MODS development in critical care settings.
    • Anesthetic support may be required for patients with MODS.