Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Donovanosis: an update.

N O'Farrell1

  • 1Pasteur Suite, Ealing Hospital, Uxbridge Road, London UB1 3HW, UK.

International Journal of STD & AIDS
|June 8, 2001
PubMed
Summary

Donovanosis, a neglected tropical disease, is resurging in South Africa and Australia. Advances in PCR diagnostics and reclassification of the causative agent may aid disease control efforts.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Significance of nodal yield after rectal resection in the TNT era: does count matter?

BMC cancer·2026
Same author

Benefit of adjuvant systemic chemotherapy in signet ring colorectal cancer: A systematic review.

Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland·2025
Same author

The financial imperative of physicians to control demand of laboratory testing.

Irish medical journal·2011
Same author

European guideline for the management of donovanosis, 2010.

International journal of STD & AIDS·2010
Same author

Pyogenic liver abscesses: diminished role for operative treatment.

The surgeon : journal of the Royal Colleges of Surgeons of Edinburgh and Ireland·2010
Same author

Foreskin length in uncircumcised men is associated with subpreputial wetness.

International journal of STD & AIDS·2008

Area of Science:

  • Infectious Diseases
  • Microbiology
  • Public Health

Background:

  • Donovanosis, a neglected tropical disease, has seen a resurgence, particularly in KwaZulu/Natal, South Africa, where it may increase HIV risk in men.
  • The causative organism, Calymmatobacterium granulomatis, was recently cultured after a 30-year gap, and its similarities to Klebsiella spp. noted.

Purpose of the Study:

  • To review recent advancements in understanding and managing donovanosis.
  • To highlight the potential of new diagnostic tools and taxonomic reclassification for disease control.

Main Methods:

  • Review of recent research on donovanosis epidemiology, diagnostics, and treatment.
  • Development and application of Polymerase Chain Reaction (PCR) techniques, including colorimetric detection.
  • Investigation of taxonomic relationships between Calymmatobacterium granulomatis and Klebsiella spp.

Main Results:

  • Polymerase Chain Reaction (PCR) techniques for donovanosis diagnosis have been developed.
  • Calymmatobacterium granulomatis shows significant genetic similarities to Klebsiella spp., leading to a proposal for reclassification.
  • Azithromycin is the recommended treatment, though cost remains a barrier to universal adoption. Prolonged treatment may be necessary for immunocompromised individuals.

Conclusions:

  • Polymerase Chain Reaction (PCR) testing is expected to improve donovanosis recognition and facilitate control programs.
  • An eradication program is active in Australia's aboriginal community.
  • Current syndromic management guidelines for genital ulcers require validation in endemic regions.

Related Experiment Videos