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Updated: Aug 28, 2026

Human Pluripotent Stem Cell Based Developmental Toxicity Assays for Chemical Safety Screening and Systems Biology Data Generation
Published on: June 17, 2015
Toxicology of simple and complex mixtures
J P Groten1, V J Feron, J Sühnel
1Department of Explanatory Toxicology, TNO Nutrition and Food Research, PO Box 360, 3700 AJ Zeist, The Netherlands. Groten@voeding.tno.nl
Abstract:
Humans are exposed to mixtures of chemicals, rather than to individual chemicals. From a public health point of view, it is most relevant to answer the question of whether or not the components in a mixture interact in a way that results in an increase in their overall effect compared with the sum of the effects of the individual components. In this article, options for the hazard identification and risk assessment of simple and complex chemical mixtures will be discussed. In addition, key research needed to continue the development of hazard characterization of chemical mixtures will be described. Clearly, more collaboration among toxicologists, model developers and pharmacologists will be necessary.
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