Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Histone acetyltransferases.

S Y Roth1, J M Denu, C D Allis

  • 1Department of Biochemistry and Molecular Biology, University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA. syr@mdacc.tmc.edu

Annual Review of Biochemistry
|June 8, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Reading between the Lines: "ADD"-ing Histone and DNA Methylation Marks toward a New Epigenetic "Sum".

ACS chemical biology·2018
Same author

Investigating Histone Acetylation Stoichiometry and Turnover Rate.

Methods in enzymology·2016
Same author

HIRA and Daxx constitute two independent histone H3.3-containing predeposition complexes.

Cold Spring Harbor symposia on quantitative biology·2010
Same author

Identification of protein interactions by far Western analysis.

Current protocols in molecular biology·2008
Same author

Identification of protein interactions by far Western analysis.

Current protocols in cell biology·2008
Same author

Linking the epigenetic 'language' of covalent histone modifications to cancer.

British journal of cancer·2007
Same journal

Lactate as a Chemical Modification on Proteins and Metabolites.

Annual review of biochemistry·2026
Same journal

Nucleocytoplasmic Transport.

Annual review of biochemistry·2026
Same journal

Packaging of Single-Stranded RNA in Viruses and Virus-Like Particles.

Annual review of biochemistry·2026
Same journal

Shaping of the Infant Gut Microbiome by Milk Oligosaccharides.

Annual review of biochemistry·2026
Same journal

Proteostasis Deregulation by Metabolism Drives the Hallmarks of Cancer.

Annual review of biochemistry·2026
Same journal

JoAnne Stubbe's Radical Path: A Story of Passion, Curiosity, and Persistence.

Annual review of biochemistry·2026
See all related articles

Histone acetyltransferases (HATs) regulate gene transcription by modifying histones. These enzymes are crucial for development, differentiation, and oncogenesis, highlighting their broad biological impact.

Area of Science:

  • Molecular Biology
  • Biochemistry
  • Genetics

Background:

  • Gene transcription in eukaryotes is modulated by chromatin structure, particularly histone proteins.
  • Histone acetylation, a reversible modification of lysine residues, is strongly associated with transcriptional activation.
  • Multisubunit enzyme complexes, known as histone acetyltransferases (HATs), catalyze targeted histone acetylation.

Purpose of the Study:

  • To review the current understanding of histone acetyltransferases (HATs).
  • To discuss their discovery, substrate specificity, catalytic mechanisms, regulation, and functional roles in transcription and chromatin modification.
  • To highlight emerging connections to cellular regulatory processes and disease.

Main Methods:

  • Literature review of biochemical and genetic studies.

Related Experiment Videos

  • Analysis of enzyme complex identification and characterization.
  • Synthesis of current knowledge on HAT function and regulation.

    • Main Results:

    • HATs are large, multisubunit complexes involved in targeted histone acetylation.
    • These enzymes link transcriptional regulation to chromatin modification.
    • Recent findings reveal unexpected roles in normal development, differentiation, and oncogenesis.

    Conclusions:

    • Histone acetyltransferases play fundamental roles in eukaryotic gene regulation.
    • Understanding HATs and their regulation is critical for comprehending human biology and disease.
    • Further research into HATs promises significant implications for human health and disease pathologies.