Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Transcriptional coactivator complexes.

A M Näär1, B D Lemon, R Tjian

  • 1Howard Hughes Medical Institute, Department of Molecular and Cell Biology, 401 Barker Hall, University of California, Berkeley, California 94720, USA. anders@uclink4.berkeley.edu

Annual Review of Biochemistry
|June 8, 2001
PubMed
Summary

Eukaryotic gene activity relies on coactivators, which link DNA activators to transcription machinery and manage chromatin. These factors form modular complexes with adaptable functions, crucial for gene regulation.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Structure of the human Mediator-bound transcription preinitiation complex.

Science (New York, N.Y.)·2021
Same author

MicroRNAs in metabolism and metabolic diseases.

Cold Spring Harbor symposia on quantitative biology·2011
Same author

An unexpected role of TAFs and TRFs in skeletal muscle differentiation: switching core promoter complexes.

Cold Spring Harbor symposia on quantitative biology·2008
Same author

Transcriptional regulation in Drosophila: the post-genome challenge.

Functional & integrative genomics·2002
Same author

Selectivity of chromatin-remodelling cofactors for ligand-activated transcription.

Nature·2002
Same author

Requirement of tissue-selective TBP-associated factor TAFII105 in ovarian development.

Science (New York, N.Y.)·2001

Area of Science:

  • Molecular Biology
  • Cell Biology
  • Genetics

Background:

  • Eukaryotic gene expression is tightly regulated.
  • Coactivators are essential for controlling gene activity.
  • Understanding coactivator mechanisms is key to transcriptional control.

Purpose of the Study:

  • To review the discovery and functions of coactivators.
  • To explore the structure and modular assembly of coactivator complexes.
  • To highlight the interplay of coactivator functions in gene regulation.

Main Methods:

  • Biochemical strategies
  • Genetic approaches
  • Molecular and cellular techniques

Main Results:

Related Experiment Videos

  • Coactivators connect DNA-binding activators to the transcriptional machinery.
  • Coactivators facilitate navigation of chromatin constraints.
  • Coactivator functions include adaptor roles and chromatin remodeling/modification.
  • Coactivator complexes exhibit modular assembly with shared subunits.

Conclusions:

  • Coactivator complexes are assembled modularly, providing cellular versatility.
  • Functional interplay between coactivator activities is critical for gene-specific regulation.
  • Coactivator research remains a dynamic and evolving field.