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Updated: Oct 7, 2026
Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay
Published on: February 9, 2021
(S)-(-)-Bromofosfamide (CBM-11): synthesis and antitumor activity and toxicity in mice
K Misiura1, R W Kinas, H Kuśnierczyk
1Department of Bioorganic Chemistry, Centre of Molecular and Macromolecular Studies, Polish Academy of Sciences, Sienkiewicza 112, 90-363 Lódz, Poland. kmisiura@bio.cbmm.lodz.pl
Abstract:
(S)-(-)-Bromofosfamide (CBM-11), an enantiomerically pure bromo analog of ifosfamide, was found to be potent against several model tumors in mice. Therapeutic indices of CBM-11 were more favorable as compared to those received for ifosfamide.
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