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Growth hormone receptor gene variant and mandibular height in the normal Japanese population.

T Yamaguchi¹, K Maki, Y Shibasaki

¹Department of Orthodontics, School of Dentistry, Showa University, Tokyo, Japan. tetsu@senzoku.showa-u.ac.jp

American Journal of Orthodontics and Dentofacial Orthopedics : Official Publication of the American Association of Orthodontists, Its Constituent Societies, and the American Board of Orthodontics

|June 8, 2001

Summary

This summary is machine-generated.

The Pro561Thr (P56IT) variant in the growth hormone receptor gene (GHR) may influence mandibular height. Individuals without this GHR gene variant showed significantly greater mandibular ramus length, suggesting a potential genetic marker for craniofacial growth.

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Area of Science:

Genetics
Anthropology
Endocrinology

Background:

Craniofacial and skeletal growth are influenced by genetic factors.
The growth hormone receptor gene (GHR) plays a role in development.
The Pro561Thr (P56IT) variant of the GHR gene is of interest for its potential impact on growth.

Purpose of the Study:

To quantitatively assess the association between craniofacial morphology and the GHR gene P56IT variant.
To investigate the GHR P56IT variant's role in skeletal and craniofacial development in a Japanese population.

Main Methods:

Genotyping for the GHR P56IT variant using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) with StuI.
Analysis of craniofacial morphology using 5 linear measurements from lateral cephalograms.
Statistical comparison of craniofacial measurements between genotypes in 100 healthy Japanese individuals.

Main Results:

A significant difference in mandibular ramus length (condylion-gonion) was observed between individuals with and without the GHR P56IT variant.
The normal Japanese population without the P56IT variant exhibited a greater mandibular ramus length compared to those with the variant.

Conclusions:

The GHR gene P561Thr (P56IT) variant may be associated with mandibular height growth.
This variant could serve as a genetic marker for predicting craniofacial growth patterns.
Further research into genetic markers can enhance understanding of craniofacial development determinants.