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[Bullous cutaneous mastocytosis revealed by acute disease secondary to morphine administration]
L Leblanc1, J V de Monléon, V Faber
1Service de dermatologie, centre hospitalier universitaire de Dijon, 10, boulevard du Maréchal-de-Lattre-de-Tassigny, 21034 Dijon, France.
Insights
Bullous cutaneous mastocytosis is a rare pediatric skin condition. Early diagnosis and treatment are crucial for managing severe symptoms and ensuring normal development.
Area of Science:
- Pediatric Dermatology
- Hematology
Background:
- Mastocytosis presents in children with three clinical forms, the rarest being the diffuse or bullous type.
- Bullous cutaneous mastocytosis is an uncommon pediatric dermatological condition.
Observation:
- An infant presented with diffuse erythema and a vesicle rash from one month of age.
- At four months, severe discomfort post-morphine administration prompted diagnosis of bullous cutaneous mastocytosis.
- Histologic examination confirmed the diagnosis of bullous cutaneous mastocytosis.
Findings:
- The infant's severe clinical presentation necessitated intravenous corticosteroid and antihistamine therapy.
- Histological confirmation underscored the diagnosis of bullous cutaneous mastocytosis.
Implications:
- Bullous cutaneous mastocytosis, though rare in children, warrants consideration due to potential severe complications and therapeutic risks.
- Prompt and appropriate management, including potential intravenous corticosteroid therapy, can lead to normal development and disease resolution before adolescence.
Unlabelled:
Mastocytosis in children shows in three clinical forms. The rarest is the diffuse or bullous form.
Case Report:
Since one month of age an infant showed a diffuse erythema and vesicle rash. At four months of age, serious discomfort after morphinic absorption led to the diagnosis of bullous cutaneous mastocytosis. Histologic examination confirmed this diagnosis. The clinical severity led to intravenous corticosteroid and antihistamine therapy.
Comments:
Bullous cutaneous mastocytosis is unusual in children. However, it should be considered if there are any doubts because of its serious complications and iatrogenic therapeutic risks. Some serious cases require intravenous corticosteroid therapy. Appropriate care enables a normal development with a disappearance of the disease before the teenage years.
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