Related Experiment Video
Updated: Aug 15, 2026

09:36
Studying Oxidative Stress Caused by the Mitis Group Streptococci in Caenorhabditis elegans
Published on: March 23, 2019
Necrotizing enterocolitis in a married couple due to a staphylococcal toxin
R J Lieverse1, J van Hooft, G Fedder
1Department of Internal Medicine, Gelre Hospitals, Apeldoorn, The Netherlands. RJ.Lieverse@zca.nl
European Journal of Gastroenterology & Hepatology
|June 9, 2001
Summary
A married couple developed necrotizing enterocolitis (NEC) due to the same toxin-producing Staphylococcus aureus strain. This suggests a potential shared environmental exposure or transmission route for this severe gastrointestinal condition.
Area of Science:
- Gastroenterology
- Infectious Diseases
- Microbiology
Background:
- Necrotizing enterocolitis (NEC) is a serious condition primarily affecting premature infants.
- While rare in adults, NEC can occur under specific circumstances.
Observation:
- A case study involving a married couple presenting with necrotizing enterocolitis.
- Both individuals were infected with the identical toxin-producing Staphylococcus aureus strain.
Findings:
- The identified Staphylococcus aureus strain was implicated as the causative agent for NEC in both patients.
- This finding highlights the potential pathogenicity of specific S. aureus strains in adult NEC.
Implications:
- Suggests a possible shared source or transmission of Staphylococcus aureus between the couple.
- Underscores the need to consider S. aureus in adult NEC differential diagnoses.
- Warrants further investigation into non-infant transmission routes of pathogenic S. aureus.
Related Concept Videos
Bacterial Toxins
Bacterial toxins are sophisticated virulence factors that enable pathogenic bacteria to interact with, invade, and damage host tissues. These toxins fall broadly into two types: protein exotoxins, which are secreted into the environment and target specific host receptors, and lipopolysaccharide endotoxins, which are structural components of the bacterial outer membrane released primarily during bacterial lysis or membrane shedding. Exotoxins generally act more selectively, binding to cell...
Determinants of Bacterial Pathogenicity and Virulence
Pathogenic bacteria employ a variety of strategies to establish infections, including the secretion of extracellular enzymes that act as potent virulence factors. These enzymes facilitate bacterial colonization of host tissues and help evade immune surveillance. By targeting structural components of host tissues and interfering with immune mechanisms, these enzymes play a pivotal role in disease progression.Extracellular Enzymes Facilitating Tissue Invasion: Several bacterial pathogens secrete...
Staphylococcal Skin Infections
Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...
Botulism
Botulism is a life-threatening neuroparalytic condition caused by botulinum neurotoxin, which is produced by the bacterium Clostridium botulinum, a Gram-positive, spore-forming, obligate anaerobe.In adults, the toxin enters the body in different ways: in foodborne botulism, the preformed toxin is absorbed in the intestine. In wound botulism, spores grow in injured tissue and release the toxin into the blood. Infant botulism differs mechanistically from adult forms. In infants, botulism commonly...
Bacterial Gastroenteritis
Bacterial gastroenteritis, characterized by diarrhea, abdominal cramps, and vomiting, is often caused by ingestion of contaminated food or water and is frequently associated with pathogenic Escherichia coli strains. These microbes exploit two principal mechanisms to inflict disease.Shiga toxin–producing E. coli, also referred to as STEC—notably O157:H7—release Shiga toxins that target ribosomes, blocking protein synthesis. The B subunit of the toxin binds the host glycolipid receptor...
Amebiasis
Entamoeba histolytica, a protozoan parasite, is responsible for intestinal and extraintestinal amebiasis. Though a significant proportion of infections remain asymptomatic, approximately 50 million individuals annually are estimated to present with clinical disease, resulting in up to 100,000 deaths globally. The disease burden is disproportionately high in regions with lower socioeconomic status, such as parts of India, Africa, Mexico, and Latin America.Etiology and TransmissionThe infective...

