Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Formation of dextran hydrogels by crystallization.

R J Stenekes1, H Talsma, W E Hennink

  • 1Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, University Utrecht, The Netherlands.

Biomaterials
|June 9, 2001
PubMed
Summary

Researchers developed a new method to create dextran hydrogels and microspheres using crystallization. This technique leverages controlled precipitation of dextran 6000 in concentrated solutions to form water-insoluble materials.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A highly absorbing substrate based on functionalized calcium carbonate for personalized dosing of clonidine by drop-on dispensing.

International journal of pharmaceutics·2026
Same author

Development of a compounded propofol nanoemulsion using multiple non-invasive process analytical technologies.

International journal of pharmaceutics·2023
Same author

Preparation and characterization of inorganic radioactive holmium-166 microspheres for internal radionuclide therapy.

Materials science & engineering. C, Materials for biological applications·2019
Same author

Radioactive holmium phosphate microspheres for cancer treatment.

International journal of pharmaceutics·2018
Same author

Assessing bioink shape fidelity to aid material development in 3D bioprinting.

Biofabrication·2017
Same author

Overcoming multidrug resistance using folate receptor-targeted and pH-responsive polymeric nanogels containing covalently entrapped doxorubicin.

Nanoscale·2017

Area of Science:

  • Polymer Chemistry
  • Materials Science
  • Biomaterials Engineering

Background:

  • Dextrans are generally water-soluble polysaccharides.
  • Controlled precipitation of dextrans for material formation is not widely established.
  • Understanding dextran solution behavior is crucial for developing novel biomaterials.

Purpose of the Study:

  • To present a novel method for preparing dextran hydrogels and microspheres.
  • To investigate the crystallization-based precipitation of dextran.
  • To characterize the resulting dextran materials.

Main Methods:

  • Preparation of concentrated aqueous solutions of low molecular weight dextran (dextran 6000).
  • Induction of precipitation through controlled conditions (concentration, stirring, salts).

Related Experiment Videos

  • Characterization using IR spectroscopy and differential scanning calorimetry (DSC).

    • Main Results:

    • Precipitation and formation of crystalline dextran hydrogels and microspheres were achieved from concentrated dextran 6000 solutions.
    • Precipitation kinetics were dependent on dextran concentration, stirring, and salt presence.
    • The crystalline precipitates were insoluble in water at room temperature but soluble in boiling water or DMSO.

    Conclusions:

    • Crystallization is a viable method for producing dextran-based hydrogels and microspheres.
    • The process is influenced by polymer concentration and external factors like stirring and salts.
    • Hydrogen bonding in concentrated solutions is hypothesized to drive the observed crystallization.