Total calcium ultrastructure: advances in excitable cells

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Direct Imaging of ER Calcium with Targeted-Esterase Induced Dye Loading (TED)
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J Meldolesi1, F Grohovaz

  • 1Department of Neurosciences, S. Raffaele Institute and Vita-Salute S. Raffaele University, Milan, Italy. meldolesi.jacopo@hsr.it

Cell Calcium
|June 9, 2001
PubMed

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Feedback Regulation of Calcium Concentration01:27

Feedback Regulation of Calcium Concentration

Calcium is an essential signaling molecule required for various cellular functions. Calcium pumps and ion channels on cell and organellar membranes, such as those on the endoplasmic reticulum (ER), regulate calcium concentrations inside the cell. They remain closed, keeping the cytosolic calcium levels low at a resting state.
Various transmembrane receptors, such as G protein-coupled receptors (GPCRs), elicit a response to extracellular signals by increasing cytosolic calcium. Activated GPCRs...