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High Content Screening Analysis to Evaluate the Toxicological Effects of Harmful and Potentially Harmful Constituents (HPHC)
11:38

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Published on: May 10, 2016

Health risk assessment of 1,3-butadiene as a Priority Substance in Canada

K Hughes1, M E Meek, M Walker

  • 1Environmental Health Directorate, Health Canada, Tunney's Pasture PL0802B1, Ottawa, Ontario, Canada K1A 0L2. kathy_hughes@hc-sc.gc.ca

Chemico-Biological Interactions
|June 9, 2001
PubMed

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The addition of a hydrogen halide to 1,3-butadiene gives a mixture of 1,2- and 1,4-adducts. Since more substituted alkenes are more stable, the 1,4-adduct is expected to be the major product. However, the product distribution is strongly influenced by temperature; low temperature favors the 1,2-adduct, whereas the 1,4-adduct is predominant at high temperature.
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Conjugated dienes have lower heats of hydrogenation than cumulated and isolated dienes, making them more stable. The enhanced stabilization of conjugated systems can be understood from their π molecular orbitals.
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