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Intranasal delivery of tenoxicam in rat
1Department of Pharmaceutics, College of Pharmacy, Sri Ramakrishna Institute of Paramedical Sciences, Sri Ramakrishna Hospital campus, Coimbatore, 641044, Tamil Nadu, India. c_vijayan_2k@yahoo.com
International Journal of Pharmaceutics
|June 9, 2001
Abstract:
Intranasal delivery of tenoxicam was studied in male rats on single dose administration of 0.36 mg/rat and compared with intravenous administration. Tenoxicam plasma levels were determined by RP-HPLC method with UV detection that employed piroxicam as an electroactive internal standard in the analysis. Following intravenous administration the area under the plasma concentration curve was 2452.17+/-86.49 ng h/ml as compared to 1357.69+/-102.36 ng h/ml following intranasal dosing. This corresponds to a relative bioavailability of 55.36%.