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[Anterior uveitis and cidofovir].

M B Rougier1, D Neau, J F Viallard

  • 1Service d'Ophtalmologie, Centre Hospitalier Universitaire, Hôpital Pellegrin, Place Amélie Raba-Léon, 33076 Bordeaux Cedex.

Journal Francais D'Ophtalmologie
|June 9, 2001
PubMed
Summary

Anterior uveitis during cidofovir treatment for cytomegalovirus (CMV) disease is linked to prior CMV retinitis, immune recovery, and intraocular drug accumulation. These factors contribute to ocular inflammation in patients undergoing treatment.

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Area of Science:

  • Ophthalmology
  • Infectious Diseases
  • Pharmacology

Background:

  • Cytomegalovirus (CMV) retinitis is a serious complication, particularly in immunocompromised individuals.
  • Cidofovir is a treatment option for CMV disease, but can be associated with ocular side effects.
  • Anterior uveitis is a known adverse event during cidofovir therapy.

Purpose of the Study:

  • To identify parameters associated with the occurrence of uveitis in patients treated with cidofovir.
  • To investigate the relationship between uveitis and patient factors during cidofovir therapy.

Main Methods:

  • Retrospective analysis of 10 patients treated with cidofovir for CMV disease.
  • Ocular examinations, CD4+ lymphocyte counts, and creatinine clearance were assessed for uveitis cases.

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Main Results:

  • Twenty cases of uveitis were analyzed over 17 months, with the first attack occurring after a median of 7.6 doses.
  • Sixty-five percent of patients with ocular inflammation had improved immune function (CD4+ count >=100x10(6)/L).
  • Abnormal creatinine clearance was observed in patients with recurrent uveitis and lower CD4+ counts, suggesting potential intraocular drug accumulation.

Conclusions:

  • Anterior uveitis during cidofovir treatment is multifactorial.
  • Key contributing factors include a history of CMV retinitis, immune system recovery, and intraocular cidofovir accumulation.
  • These findings highlight the importance of monitoring specific patient parameters during cidofovir therapy.