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Related Experiment Videos

Amlodipine for migraine prophylaxis.

B K Dandapani1, M R Hanson

  • 1Department of Neurology, Cleveland Clinic Florida, 3000 West Cypress Creek Road, Fort Lauderdale, FL 33309, USA.

Headache
|June 12, 2001
PubMed
Summary
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Migraine affects 10% of the US population. This study reports successful migraine prevention in two patients using amlodipine, a calcium-channel blocker, marking its first use in migraine prophylaxis.

Area of Science:

  • Neurology
  • Pharmacology

Background:

  • Migraine is a prevalent neurologic disorder affecting approximately 10% of the US population, with higher incidence in females.
  • Current treatments include prophylactic and abortive medications, with calcium-channel blockers frequently used for prevention.

Observation:

  • Two patients experiencing migraine were treated with amlodipine, a slow calcium-channel blocker.
  • Amlodipine is commonly prescribed for hypertension and angina.

Findings:

  • Both patients with migraine experienced successful prophylactic treatment with amlodipine.
  • These cases represent the first documented use of amlodipine for migraine prophylaxis.

Implications:

  • Amlodipine may be a viable option for migraine prophylaxis in certain patient populations.

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  • Further clinical trials are warranted to confirm the efficacy and safety of amlodipine in migraine prevention.