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[NMDA receptors and their interacting proteins in the postsynaptic density]
1Department of Anatomy and Cell Biology, School of Medicine, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8519, Japan.
Kaibogaku Zasshi. Journal of Anatomy
|June 12, 2001
Summary
Glutamate receptors, crucial for brain signaling, interact with proteins like PSD-95. This review explores NMDA receptor diversity and postsynaptic density remodeling in mammalian central nervous system function.
Area of Science:
- Neuroscience
- Molecular Biology
- Biochemistry
Context:
- Excitatory synaptic transmission in the mammalian central nervous system relies on glutamate receptors and their interacting proteins.
- NMDA receptors, a key subtype of ionotropic glutamate receptors, form critical complexes with PDZ-domain proteins like PSD-95.
Purpose:
- To review the biological significance of diverse NMDA receptor subunits.
- To present implications from recent analyses on the structural remodeling of the postsynaptic density.
Summary:
- The interaction between NMDA receptors and PSD-95 is vital for clustering receptors on the postsynaptic membrane, forming the core structure of the postsynaptic density.
- This review discusses the diversity of NMDA receptor subunits and examines structural changes within the postsynaptic density.
Impact:
- Provides insights into the molecular mechanisms underlying synaptic transmission.
- Highlights the importance of NMDA receptor-PSD-95 interactions in postsynaptic structure and function.
- Contributes to understanding neurological disorders associated with synaptic dysfunction.