[Cisplatin and vinorelbine therapy of previously treated advanced breast cancer (preliminary studies)]

In this work it was investigated the efficacy of second and third line chemotherapy (vinorelbine, cisplatin/carboplatin) in patients with metastases breast cancer. The twenty pre-treated women with metastases to the liver, lung, lymph nodules and subcutaneous tissue were treated the regiment including navelbine 30 mg day 1 and 5 and cisplatin 100 mg/m2 day 1 every 3 weeks. The patients had been early received CMF and/or FAC. The total response rate was 40%. The median time to progression was 8 months. The stabilisation disease was at 20% patients. The tolerance of treatment was good and the frequent complication was leucopenia (WHO 2 and 3) and thrombocytopenia (WHO 1). The women received from 6 to 10 courses.