Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Diffusion-weighted imaging in neonates.

G M Bydder1, M A Rutherford, F M Cowan

  • 1The Robert Steiner Magnetic Resonance Unit, MRC Clinical Sciences Centre, Hammersmith Hospital, London, UK.

Child'S Nervous System : Chns : Official Journal of the International Society for Pediatric Neurosurgery
|June 12, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Comment on 'value of cranial ultrasound at initiation of therapeutic hypothermia for neonatal encephalopathy'.

Journal of perinatology : official journal of the California Perinatal Association·2022
Same author

A Uniform Description of Perioperative Brain MRI Findings in Infants with Severe Congenital Heart Disease: Results of a European Collaboration.

AJNR. American journal of neuroradiology·2021
Same author

How Can We Support the Use of Oral PrEP Among Young Women who Sell Sex? A PrEP Cascade Analysis.

Journal of acquired immune deficiency syndromes (1999)·2021
Same author

Inversion Recovery Ultrashort TE MR Imaging of Myelin is Significantly Correlated with Disability in Patients with Multiple Sclerosis.

AJNR. American journal of neuroradiology·2021
Same author

Intraventricular haemorrhage in a Ugandan cohort of low birth weight neonates: the IVHU study.

BMC pediatrics·2021
Same author

MRI Findings at Term-Corrected Age and Neurodevelopmental Outcomes in a Large Cohort of Very Preterm Infants.

AJNR. American journal of neuroradiology·2020
Same journal

Pediatric intraspinal space-occupying lesions: navigating diagnostic pitfalls, surgical complexity, and neurological outcomes in 27 cases.

Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery·2026
Same journal

Indications for and strategies to reduce blood transfusion for craniosynostosis surgery: a narrative review.

Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery·2026
Same journal

A case-control study of MRI features in pediatric atypical teratoid rhabdoid tumor and medulloblastoma.

Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery·2026
Same journal

High-dose chemotherapy with autologous stem cell rescue in children under 5 years of age with central nervous system embryonal tumors: results from a prospective cohort in an upper-middle-income country.

Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery·2026
Same journal

Advantages of the double-incision approach in endoscopic management of unicoronal synostosis.

Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery·2026
Same journal

Impact of blood product removal versus temporary cerebrospinal fluid diversion on permanent shunting rates in posthemorrhagic hydrocephalus of prematurity: a comparative meta-analysis.

Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery·2026
See all related articles

Diffusion-weighted imaging (DWI) detects early brain injury in neonates. This technique may help identify infants needing timely intervention for perinatal ischaemic injury.

Area of Science:

  • Neonatal neurology
  • Radiology
  • Medical imaging

Background:

  • Diffusion-weighted imaging (DWI) is increasingly used in adult neuroimaging.
  • Studies in neonates are fewer but growing, with DWI showing promise for assessing brain development and injury.

Purpose of the Study:

  • To explore the application and findings of DWI in neonatal brain imaging, particularly for detecting ischaemic injury.

Main Methods:

  • Utilizing pulsed gradient spin echo (PGSE) sequences with cardiac gating for DWI in neonates.
  • Measuring the apparent diffusion coefficient (D*) to assess water molecule diffusion.
  • Analyzing anisotropic properties related to restricted water movement in white matter tracts.

Main Results:

Related Experiment Videos

  • DWI can detect restricted water motion in both myelinated and unmyelinated neonatal white matter tracts.
  • Changes in D* (decrease post-insult, then gradual increase) are observed in neonatal ischaemic injury, mirroring animal data but on a slower timescale.

    • Conclusions:

    • DWI is a feasible technique in neonates, offering insights into brain tissue characteristics.
    • Early detection of ischaemic injury by DWI may facilitate prompt intervention, improving outcomes for affected infants.