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Related Experiment Videos

Acquired inflammatory white matter disease.

M Gallucci1, M Caulo, G Cerone

  • 1Istituto di Radiologia, Ospedale S. Salvatore, L'Aquila, Italy. maxgallucci@tiscalinet.it

Child'S Nervous System : Chns : Official Journal of the International Society for Pediatric Neurosurgery
|June 12, 2001
PubMed
Summary

This review examines white matter inflammatory diseases, suggesting Schilder's disease, Devic's neuromyelitis optica, and Balo's concentric sclerosis may be multiple sclerosis variants. It also explores intermediate cases between these conditions and acute disseminated encephalomyelitis.

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Area of Science:

  • Neurology
  • Neuroimmunology
  • Demyelinating Diseases

Background:

  • Defining white matter inflammatory diseases remains challenging.
  • Schilder's disease (SD), Devic's neuromyelitis optica (NMO), and Balo's concentric sclerosis are often considered variants of multiple sclerosis (MS).
  • Pediatric MS can exhibit aggressive features, including large, tumefactive, or hemorrhagic lesions.

Purpose of the Study:

  • To review the literature on white matter inflammatory diseases.
  • To analyze atypical cases that present features intermediate between MS and other conditions like SD and NMO.
  • To critically revise cases with overlapping clinical, historical, laboratory, and MRI findings between acute disseminated encephalomyelitis (ADEM) and MS.

Main Methods:

  • Literature review.

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  • Analysis of case studies with intermediate presentations.
  • Critical revision of diagnostic criteria for overlapping conditions.

    • Main Results:

    • Evidence suggests potential overlap and intermediate forms between MS, SD, NMO, and Balo's concentric sclerosis.
    • Atypical presentations in children with MS are noted.
    • Cases with features bridging ADEM and MS are identified.

    Conclusions:

    • The classification of white matter inflammatory diseases requires ongoing critical evaluation.
    • Intermediate presentations between MS and other demyelinating disorders are recognized.
    • Further research is needed to refine diagnostic criteria for these complex conditions.