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Self-inoculation with Mycobacterium tuberculosis Weiszfeiler W-115
Acta Microbiologica Academiae Scientiarum Hungaricae
|January 1, 1979
Summary
Mycobacterium tuberculosis W-115 was tested for safety as a potential tuberculosis vaccine. The study found no adverse effects, indicating its safety for antitubercular vaccination.
Area of Science:
- Microbiology
- Immunology
- Vaccinology
Background:
- Tuberculosis remains a significant global health challenge.
- Development of novel and safe antitubercular vaccines is crucial.
- Mycobacterium tuberculosis strain W-115 is a candidate for vaccine development.
Purpose of the Study:
- To evaluate the safety and local reaction of intracutaneous inoculation with Mycobacterium tuberculosis W-115.
- To assess the viability and recultivation of the W-115 strain post-inoculation.
- To determine the safety of the W-115 strain for antitubercular vaccination.
Main Methods:
- Intracutaneous self-inoculation of 0.05 mg (wet weight) of Mycobacterium tuberculosis W-115 (approx. 600,000 viable units).
- Observation of local reactions for 9 weeks post-inoculation.
- Recultivation of the W-115 strain from the lesion site.
- Safety assessment based on animal models, including laboratory animals, monkeys, and human newborns and adults.
Main Results:
- No adverse effects or general reactions were observed after inoculation.
- The W-115 strain was successfully recultivated from the lesion, designated W-115(78)ST vaccine strain.
- Experiments demonstrated the safety of the W-115 strain.
Conclusions:
- Mycobacterium tuberculosis W-115 is safe for antitubercular vaccination.
- The W-115 strain shows comparable safety to established vaccine strains like Mycobacterium bovis BCG.
- Further studies utilizing the W-115(78)ST vaccine strain are warranted.