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Circulating N-terminal brain natriuretic peptide precursor and endothelin levels in patients with syndrome X and left

D Dudek1, L Rzeszutko, P Petkow Dimitrow

  • 1IInd Department of Cardiology, Jagiellonian University, Kopernika 17, 31-501, Krakow, Poland. mcdudek@cyf.kr.edu.pl

International Journal of Cardiology
|June 12, 2001
PubMed

Insights

Patients with syndrome X and left bundle branch block show elevated N-terminal Brain Natriuretic Peptide (NT-proBNP) and endothelin-1 levels, indicating diastolic dysfunction even with preserved systolic function.

Area of Science:

  • Cardiology
  • Cardiovascular Physiology
  • Biomarker Research

Background:

  • Syndrome X with left bundle branch block (LBBB) can lead to left ventricular (LV) dysfunction.
  • Elevated Endothelin-1 (ET-1) is common in these patients.
  • Brain Natriuretic Peptide (BNP) levels, a marker for LV dysfunction, have not been previously assessed in this cohort.

Purpose of the Study:

  • To evaluate LV diastolic function.
  • To measure N-terminal Brain Natriuretic Peptide (NT-proBNP) precursor levels.
  • To assess endothelial function biomarkers in patients with Syndrome X, LBBB, and preserved LV systolic function.

Main Methods:

  • Compared echocardiographic and neurohormonal measures in three groups: Syndrome X with LBBB (n=8), Syndrome X without LBBB (n=13), and controls (n=15).
  • Assessed NT-proBNP, ET-1, and mitral flow (E/A ratio).

Main Results:

  • Group A (Syndrome X with LBBB) exhibited significantly higher NT-proBNP levels at rest and post-exercise compared to controls.
  • Elevated ET-1 concentrations were observed in Group A compared to controls.
  • Mitral flow abnormalities, indicated by a lower E/A ratio, were found in Group A, correlating inversely with NT-proBNP levels.

Conclusions:

  • Patients with Syndrome X and LBBB have elevated NT-proBNP and ET-1, even with preserved LV systolic function.
  • LV diastolic dysfunction severity correlates with increased BNP levels, reflecting neurohormonal activation in this subgroup.
Abstract

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