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Updated: Oct 7, 2026

A Microfluidic Flow Chamber Model for Platelet Transfusion and Hemostasis Measures Platelet Deposition and Fibrin Formation in Real-time
09:38

A Microfluidic Flow Chamber Model for Platelet Transfusion and Hemostasis Measures Platelet Deposition and Fibrin Formation in Real-time

Published on: February 14, 2017

Haemostasis and Thrombosis: Current Clinical Practice: Current Management of Thrombotic Thrombocytopenic Purpura

JEROME J. Hong1, HAU C. Kwaan

  • 1Department of Internal Medicine, Division of Hematology/Oncology, Northwestern University School of Medicine, And VA Lakeside Medical Center, Chicago, IL.

Hematology (Amsterdam, Netherlands)
|June 16, 2001
PubMed

Historically, the mortality rate of thrombotic thrombocytopenic purpura (TTP) approached 100%. However, by the 1980's, new therapy was instituted with a vast improvement in survival to 90%. The exact pathogenesis of TTP remains elusive. Yet, despite incomplete understanding of the pathophysiology, outcome has improved due to increased awareness of the symptomatology leading to earlier diagnosis and better supportive care, in addition to effective therapy with plasma exchange. TTP represents a disease in which prompt diagnosis and treatment can lead to a critical difference in clinical outcome.

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