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Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus (MRSA)
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Published on: February 9, 2011

Flucloxacillin in the treatment of infectious conditions in children

J D Price, J W Harding

    Current Medical Research and Opinion
    |January 1, 1975
    PubMed

    Insights

    Flucloxacillin effectively treats common childhood infections like skin and respiratory issues. This antibiotic demonstrated high clinical success rates and good bacterial sensitivity in a multi-centre study.

    Area of Science:

    • Pediatrics
    • Infectious Diseases
    • Pharmacology

    Background:

    • Skin and soft-tissue infections (SSTIs) and upper respiratory tract infections (URTIs) are common in children.
    • Bacterial resistance to standard antibiotics like penicillin and ampicillin is a growing concern.

    Purpose of the Study:

    • To evaluate the effectiveness and tolerability of flucloxacillin in treating pediatric SSTIs and URTIs.
    • To assess the bacteriological response to flucloxacillin, particularly against Staph. aureus.

    Main Methods:

    • A multi-centre study involving 107 children diagnosed with SSTIs or URTIs.
    • Treatment with flucloxacillin (125 mg q.d.s. for 5 days).
    • Bacteriological assessment of lesion sites before and after treatment, including organism sensitivity testing.

    Main Results:

    • High clinical success rates: 93% for SSTIs and 94% for URTIs.
    • Staphylococcus aureus, a primary pathogen in SSTIs, showed resistance to penicillin and ampicillin but sensitivity to flucloxacillin.
    • Bacteriological findings correlated closely with clinical outcomes.
    • Minimal side-effects and good acceptance of the syrup formulation were reported.

    Conclusions:

    • Flucloxacillin is an effective and well-tolerated antibiotic for treating common pediatric bacterial infections.
    • It demonstrates significant activity against Staph. aureus, addressing concerns of antibiotic resistance.

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