Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Pharmacogenetics of Phase II Enzymes: N-acetyltransferase, Thiopurine S-methyltransferase, UDP-glucuronosyltransferase

Pharmacogenetics of Phase II Enzymes: N-acetyltransferase, Thiopurine S-methyltransferase, UDP-glucuronosyltransferase

Phase II biotransformation reactions are essential for detoxifying and eliminating xenobiotics, including many pharmaceutical compounds. These reactions typically involve conjugation, the covalent attachment of polar endogenous groups such as glucuronic acid, sulfate, methyl, or acetyl moieties to functional groups introduced during Phase I metabolism. The resulting conjugates are more water-soluble, enabling efficient renal or biliary excretion.The major classes of Phase II enzymes include...

Pharmacogenomics: Identification of New Drug Targets

Pharmacogenomics: Identification of New Drug Targets

Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...

Diabetic Nephropathy

Diabetic Nephropathy

Definition Diabetic nephropathy is a chronic kidney complication that results from prolonged hyperglycemia.Prevalence It is the most common cause of chronic kidney disease (CKD) and end-stage renal disease (ESRD) worldwide, affecting up to half of individuals with diabetes.Pathophysiology • Sustained hyperglycemia triggers multiple hemodynamic and metabolic changes in the kidney. • Early in the disease, increased renal blood flow and glomerular hyperfiltration occur due to afferent arteriolar...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Pathways for HCO3-reabsorption in mouse medullary collecting duct segments.

The Journal of laboratory and clinical medicine·2000

Same author

Economics of an academic renal division: an approach.

Seminars in nephrology·2000

Same author

NH4+ secretion in inner medullary collecting duct in potassium deprivation: role of colonic H+-K+-ATPase.

Kidney international·1999

Same author

HCO-3 reabsorption in renal collecting duct of NHE-3-deficient mouse: a compensatory response.

The American journal of physiology·1999

Same author

Rewarding teaching faculty with a reimbursement plan.

Journal of general internal medicine·1999

Same author

Development and implementation of a teaching practice plan in a department of medicine (1995-1998): relative teaching units (RTU's).

Transactions of the American Clinical and Climatological Association·1999

Search research articles

Related Experiment Video

Updated: Jun 5, 2026

Immunoglobulin Gene Sequence Analysis In Chronic Lymphocytic Leukemia: From Patient Material To Sequence Interpretation

Immunoglobulin Gene Sequence Analysis In Chronic Lymphocytic Leukemia: From Patient Material To Sequence Interpretation

Published on: November 26, 2018

Molecular genetics in IgA nephropathy.

¹Division of Nephrology and Hypertension, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA. john.galla@uc.edu

|June 16, 2001

Summary

Genetic factors may predispose individuals to IgA nephropathy (IgAN) and Henoch-Schönlein purpura (HSP). Understanding the genetic mechanisms of progressive renal failure in these conditions is crucial.

Area of Science:

Nephrology
Immunology
Genetics

Background:

IgA nephropathy (IgAN) and Henoch-Schönlein purpura (HSP) are kidney diseases with unclear genetic links.
These conditions are notably uncommon in Black populations, a phenomenon yet to be explained.
Existing research has not consistently linked specific genotypes or HLA antigens to disease development or progression.

Purpose of the Study:

To explore potential genetic predispositions to IgAN and HSP.
To investigate factors contributing to the progression of these diseases to chronic renal failure.
To examine the role of IgA immunobiology and complement pathways in disease pathogenesis.

Main Methods:

Review of genotypic and phenotypic evidence related to IgAN and HSP.

More Related Videos

Detection of MicroRNA Expression in the Kidneys of Immunoglobulin A Nephropathic Mice

Detection of MicroRNA Expression in the Kidneys of Immunoglobulin A Nephropathic Mice

Published on: July 8, 2020

Dioscin Mediated IgA Nephropathy Alleviation by Inhibiting B Cell Activation In Vivo and Decreasing Galactose-Deficient IgA1 Production In Vitro

Dioscin Mediated IgA Nephropathy Alleviation by Inhibiting B Cell Activation In Vivo and Decreasing Galactose-Deficient IgA1 Production In Vitro

Published on: October 13, 2023

Related Experiment Videos

Last Updated: Jun 5, 2026

Immunoglobulin Gene Sequence Analysis In Chronic Lymphocytic Leukemia: From Patient Material To Sequence Interpretation

Immunoglobulin Gene Sequence Analysis In Chronic Lymphocytic Leukemia: From Patient Material To Sequence Interpretation

Published on: November 26, 2018

Detection of MicroRNA Expression in the Kidneys of Immunoglobulin A Nephropathic Mice

Detection of MicroRNA Expression in the Kidneys of Immunoglobulin A Nephropathic Mice

Published on: July 8, 2020

Dioscin Mediated IgA Nephropathy Alleviation by Inhibiting B Cell Activation In Vivo and Decreasing Galactose-Deficient IgA1 Production In Vitro

Dioscin Mediated IgA Nephropathy Alleviation by Inhibiting B Cell Activation In Vivo and Decreasing Galactose-Deficient IgA1 Production In Vitro

Published on: October 13, 2023

Analysis of the association between IgA immunobiology, complement factor 3, and disease progression.

Consideration of the potential role of angiotensin-related polymorphisms.

Main Results:

No consistent genetic or HLA associations have been identified for IgAN or HSP.
Complement factor 3 is universally present with IgA deposition, but pathway abnormalities are sporadic.
The role of angiotensin-converting enzyme alleles in IgAN progression remains uncertain.

Conclusions:

A potential structural defect in IgA1, stemming from an unidentified genetic defect, is a promising area of investigation for IgA deposition.
The underlying genetic mechanisms driving progressive renal failure in IgAN and other glomerular diseases are of critical importance.
Further research is needed to elucidate the genetic underpinnings of IgAN and HSP progression.