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Epileptic manifestations induced by midazolam in the neonatal period
M A Montenegro1, M M Guerreiro, J P Caldas
1Department of Neurology, Faculty of Medical Sciences, University of Campinas, Campinas, SP, Brazil.
Abstract:
Antiepileptic drugs may cause worsening of epilepsy by aggravating pre-existing seizures or by triggering new seizure types. There are several reports of adverse effects related to midazolam, but only a few authors reported epileptic manifestations. We report four newborns seen at the Neonatal Intensive Care Unit of our University Hospital, who developed seizures a few seconds after the administration of midazolam. It is difficult to identify the patients at risk, but it is important to be aware and recognize this situation.
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