Related Experiment Video
Updated: Jul 21, 2026

A Toolkit to Enable Hydrocarbon Conversion in Aqueous Environments
Published on: October 2, 2012
Aldehyde analysis by high performance liquid chromatography/tandem mass spectrometry
I C O'Brien-Coker1, G Perkins, A I Mallet
1University of Greenwich, Wellington Street, London, SE18 6PF, UK.
Abstract:
This paper describes the development of a high performance liquid chromatography/tandem mass spectrometric (MS/MS) procedure for the specific qualitative and quantitative analysis of lipid aldehydes in biological matrices. A derivatisation method, which results in molecules that exhibit a common product ion on MS/MS, permits informative precursor ion scans, at high sensitivity. This has been applied to the examination of plasma in order to examine the production of aldehydes consequent on in vitro lipid oxidation. Quantitative analysis of target molecules using multiple reaction monitoring has been developed to permit quantitation in the same matrices.
More Related Videos
11:44Qualitative Characterization of the Aqueous Fraction from Hydrothermal Liquefaction of Algae Using 2D Gas Chromatography with Time-of-flight Mass Spectrometry
Published on: March 6, 2016
11:14Rapid High-throughput Species Identification of Botanical Material Using Direct Analysis in Real Time High Resolution Mass Spectrometry
Published on: October 2, 2016
Related Concept Videos
IR and UV–Vis Spectroscopy of Aldehydes and Ketones
NMR Spectroscopy and Mass Spectrometry of Aldehydes and Ketones
Mass Spectrometry: Alcohol Fragmentation
Mass Spectrometry: Aldehyde and Ketone Fragmentation
Mass Spectrometry: Complex Analysis
GC–MS is a powerful hyphenated method commonly used in forensics and environmental...
High-Performance Liquid Chromatography: Types of Detectors