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Pleuropulmonary blastoma: an aggressive intrathoracic neoplasm of childhood
C Perdikogianni1, E Stiakaki, V Danilatou
1Department of Pediatric Hematology/Oncology, University Hospital of Heraklion, 71500 Crete, Greece.
Abstract:
A case of a 4-year-old girl with pleuropulmonary blastoma is reported. Surgical resection of the tumor was performed and histologic examination revealed pleuropulmonary blastoma with rhabdomyosarcomatous differentiation. Postoperative chemotherapy was administered and 3 weeks after initiation of treatment protocol a second site of lesion in the retroperitoneum was revealed with extension to the mediastinum, which shared similar mesenchymal neoplastic characteristics to the previously diagnosed primary lesion. The girl died 4 1/2 months after initial evidence of disease because of brain metastasis, indicating a very aggressive neoplasm unresponsive to treatment.
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