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Childhood T-cell acute lymphoblastic leukemia with four distinct immunophenotypes representing different stages of
1Department of Clinical Laboratory and Medicine, Tohoku University School of Medicine, 1-1 Seiryou-machi, Aoba-ku, Sendai, 980-8574, Japan. tm30130@mail.cc.tohoku.ac.jp
Abstract:
The authors report on a 14-year-old boy who developed T-cell acute lymphoblastic leukemia (FAB:L1) displaying 4 immunophenotypically distinct leukemic cell populations by 3-color immunofluorescence staining. Cytogenetic analysis at diagnosis showed 46,XY,add(4)(p16)[12]/46,XY[2]. A single rearrangement of the T-cell antigen receptor beta- and gamma-chain genes in these cells indicated monoclonality of the leukemic cells. These findings suggest that leukemic blast cells of monoclonal origin in this case were divided into 4 immunophenotypic populations, representing various stages of differentiation.