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Recurrent Epstein-Barr virus associated disease in a cardiac transplant patient: evolution from plasmacytic
L M Larratt1, M Hamilton, R Coupland
1Department of Medicine, University of Alberta, Edmonton, Alberta, Canada. llarratt@cha.ab.ca
Abstract:
An Epstein-Barr virus (EBV)-seronegative 31-year-old male underwent cardiac transplantation in 1991 for congenital cardiomyopathy. He presented with a protracted course of waxing and waning lymphadenopathy beginning four years after transplantation with eventual progression to a fulminant EBV-positive large cell lymphoma eight years after transplantation. Risk factors for the development of post-transplant lymphoproliferative disease in this patient, the importance of a standardized approach to pathology in assessing therapeutic options, and the management strategies used are discussed.