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Related Experiment Videos

Neonatal screening program in Rajavithi Hospital, Thailand.

V Ratrisawadi1, S Horpaopan, U Chotigeat

  • 1Queen Sirikit National Institute of Child Health, Children's Hospital, Bangkok, Thailand.

The Southeast Asian Journal of Tropical Medicine and Public Health
|June 13, 2001
PubMed
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Newborn screening in Thailand identified congenital hypothyroidism (1:4,629) and glucose-6 phosphate dehydrogenase (G6PD) deficiency (5.13%). Phenylketonuria (PKU) was not detected, highlighting the importance of early detection programs.

Area of Science:

  • Neonatal screening
  • Public health
  • Pediatric genetics

Background:

  • Congenital hypothyroidism, phenylketonuria (PKU), and glucose-6 phosphate dehydrogenase (G6PD) deficiency are significant newborn health concerns.
  • Early detection and intervention are crucial for preventing long-term complications associated with these disorders.
  • A pilot screening program was initiated at Rajavithi Hospital to assess the incidence of these conditions.

Purpose of the Study:

  • To determine the incidence of congenital hypothyroidism, PKU, and G6PD deficiency in newborns at Rajavithi Hospital.
  • To evaluate the effectiveness of a newborn screening program in a hospital setting.
  • To provide data for public health strategies regarding newborn health surveillance.

Main Methods:

  • Congenital hypothyroidism screening involved measuring thyroid stimulating hormone (TSH) via radioimmunometric assay in 32,407 infants.

Related Experiment Videos

  • Phenylketonuria (PKU) screening was performed on 17,421 infants by measuring phenylalanine levels using the Guthrie method.
  • Glucose-6 phosphate dehydrogenase (G6PD) deficiency screening utilized a fluorescent screening technique for 24,714 newborns.

    • Main Results:

    • Seven cases of congenital hypothyroidism were identified, with an incidence of 1:4,629 live births.
    • No cases of phenylketonuria (PKU) were detected during the study period.
    • The overall incidence of G6PD deficiency was 5.13%, with higher rates in males (9.13%) than females (1.66%).

    Conclusions:

    • The screening program demonstrated success in the early detection of congenital hypothyroidism and G6PD deficiency.
    • The findings underscore the value of implementing comprehensive newborn screening protocols.
    • Continued surveillance and early treatment are essential for managing these inherited metabolic and endocrine disorders in newborns.