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Induction of oxidative stress in antitubercular drug-induced hepatotoxicity
A Chowdhury1, A Santra, S Kundu
1Department of Gastroenterology, Institute of Post Graduate Medical Education and Research, Kolkata. achowdhury@apexmail.com
Background And Aim:
Oxidative stress could play a role in the pathogenesis of antitubercular drug (ATD)-induced hepatotoxicity. We therefore studied the plasma level of reduced glutathione (GSH) and malondialdehyde (MDA) in patients with ATD-induced hepatotoxicity (cases), ATD-treated controls (disease controls) and in healthy volunteers.
Methods:
This study was carried out in a case-control design. Twenty-one cases, 21 age- and sex-matched disease controls, and 10 healthy volunteers were enrolled. Plasma levels of GSH and MDA were measured.
Results:
Plasma levels of GSH (median [range] 11.5 [6.2-21.2] mmol/dL) and MDA (1390 [560-2310] nmol/dL) of cases were significantly different (p<0.01) from GSH (18.4 [10.5-24.4]) and MDA (290 [240-550]) of disease controls. Further, plasma GSH and MDA levels of both the ATD-treated groups were different from those in healthy controls.
Conclusion:
Lower levels of plasma GSH and higher levels of MDA may be due to oxidative stress resulting from ATD therapy.