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Active transport of nitrofurantoin into human milk
P M Gerk1, R J Kuhn, N S Desai
1Division of Pharmacy Practice and Science, College of Pharmacy, University of Kentucky, Lexington 40536-0082, USA.
Study Objective:
To determine the extent to which nitrofurantoin is transferred into human milk.
Design:
Prospective, single-dose pharmacokinetic study.
Setting:
University-affiliated clinical research center.
Patients:
Four healthy lactating women 8-26 weeks postpartum.
Intervention:
All subjects received a single, oral, 100-mg dose of nitrofurantoin macrocrystals with food. Serial serum and milk samples were obtained and analyzed by high-performance liquid chromatography.
Measurements And Main Results:
Milk pH, milk fat partitioning, and protein binding in serum and milk were determined. Predicted milk:serum ratio (M:S) was compared with the observed M:S. Nitrofurantoin M:S predicted was 0.28+/-0.05, whereas M:S observed was 6.21+/-2.71. Average milk concentration was 1.3 mg/L, and estimated suckling infant dosage was 0.2 mg/kg/day or 6% of maternal dose (mg/kg).
Conclusions:
Nitrofurantoin is actively transported into human milk, achieving concentrations in milk greatly exceeding those in serum. Concern is warranted for suckling infants younger than 1 month old, or for infants with a high frequency of glucose-6-phosphate dehydrogenase deficiency or sensitivity to nitrofurantoin.