Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Simvastatin-associated memory loss.

A Orsi1, O Sherman, Z Woldeselassie

  • 1Pharmacy Program, Bronx VA Medical Center, New York 10468, USA.

Pharmacotherapy
|June 13, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Generation of iPSC lines derived from skin fibroblasts of two healthy controls using non-transmissible form of Sendai Virus.

Stem cell research·2024
Same author

Generation of an iPSC line from skin fibroblasts of a patient with Joubert syndrome carrying the homozygous loss of function variant c.787dupC in the AHI1 gene.

Stem cell research·2022
Same author

Detection of influenza A(H1N1)pdm09 virus in a patient travelling from Shanghai to Italy in July 2018: an uncommon clinical presentation in a non-seasonal period.

Journal of preventive medicine and hygiene·2019
Same author

Vaccination coverage in healthcare workers: a multicenter cross-sectional study in Italy.

Journal of preventive medicine and hygiene·2019
Same author

How should vaccination services be planned, organized, and managed? Results from a survey on the Italian vaccination services.

Annali di igiene : medicina preventiva e di comunita·2019
Same author

Hexavalent vaccines: characteristics of available products and practical considerations from a panel of Italian experts.

Journal of preventive medicine and hygiene·2018
Same journal

Comment on "Pharmacokinetic Analysis of Intravenous Push Cefepime in Critically Ill Patients With Sepsis".

Pharmacotherapy·2026
Same journal

Response to Comment on "Pharmacokinetic Analysis of Intravenous Push Cefepime in Critically Ill Patients With Sepsis".

Pharmacotherapy·2026
Same journal

The Effect of Multiple Doses of Itraconazole on the Pharmacokinetics of a Single Oral Dose of Zongertinib in Healthy Male Volunteers.

Pharmacotherapy·2026
Same journal

Menopausal Hormone Therapy: A Narrative Review of Contemporary Evidence.

Pharmacotherapy·2026
Same journal

Getting It Right the Second Time: How Can we Optimize First-Generation Cephalosporin Dosing for Skin and Soft Tissue Infections in the 21st Century?

Pharmacotherapy·2026
Same journal

Buprenorphine Initiation During Extracorporeal Membrane Oxygenation Decreases Sedative and Opioid Exposure: A Retrospective Matched Case-Control Study.

Pharmacotherapy·2026
See all related articles

Statins, used for high cholesterol, can rarely cause serious side effects like memory loss. Switching to a different statin, pravastatin, resolved the memory issues in one patient.

Area of Science:

  • Pharmacology
  • Neuroscience
  • Cardiovascular Medicine

Background:

  • Statins are a cornerstone therapy for managing dyslipidemias, effectively lowering cholesterol levels.
  • While generally well-tolerated, statin medications can rarely precipitate severe adverse reactions.
  • Hypercholesterolemia management requires careful monitoring for potential drug-induced complications.

Observation:

  • A 51-year-old male patient on simvastatin for hypercholesterolemia developed progressive, delayed-onset memory loss.
  • The patient's cognitive decline was temporally associated with his statin therapy.
  • Discontinuation of simvastatin was considered due to the neurological adverse effect.

Findings:

  • Switching the patient's dyslipidemia treatment from simvastatin to pravastatin resulted in the gradual resolution of memory loss.

Related Experiment Videos

  • The adverse effect of memory impairment fully resolved within one month post-switch.
  • No recurrence of memory loss was observed after transitioning to pravastatin, suggesting a causal link.

    • Implications:

    • This case highlights a rare but significant potential neurological adverse effect of statin therapy, specifically simvastatin.
    • Physicians should consider statin-induced cognitive impairment in patients presenting with unexplained memory loss.
    • Individual patient responses to statins can vary, necessitating personalized treatment adjustments and vigilant monitoring for adverse events.