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WISP-2: a serum-inducible gene differentially expressed in human normal breast epithelial cells and in MCF-7 breast
M N Zoubine1, S Banerjee, N K Saxena
1Cancer Research Unit, Research Division, VA Medical Center and Department of Medicine, Kansas City, Missouri 64128, USA.
Abstract:
WISP-2 is a Wnt-1-induced signaling protein identified as a member of CCN growth factor family. A role for this molecule during tumorigenesis is suspected but remains unproven. Here we show that WISP-2 expression was undetectable, or minimally detectable, in nontransformed human mammary epithelial cells, but was overexpressed in MCF-7 cells. Expression of WISP-2 in MCF-7 cells was modulated by serum and correlated with the serum-induced MCF-7 tumor cell proliferation, suggesting that WISP-2 is serum responsive and may be a positive regulator of tumor cell proliferation.
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