Related Experiment Videos
Olmsted syndrome
E Fonseca1, C Peña, J Del Pozo
1Department of Dermatology, Hospital Juan Canalejo, La Coruña, Spain. fonseca@canalejo.org
Journal of Cutaneous Pathology
|June 13, 2001
Abstract:
Olmsted syndrome is an uncommon inherited disorder of keratinization that presents mutilating palmoplantar keratoderma, perioral hyperkeratosis, leukokeratosis and alopecia. We report a case of this rare syndrome diagnosed in a 48-year-old woman and confirms the existence of a generalized abnormality in keratin expression. Immunoreactivity in our case suggests an abnormal expression of keratins 5 and 14 similar to the observed in other hyperproliferative disorders.