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Updated: May 13, 2026

A Modified Simple Method for Induction of Myocardial Infarction in Mice
04:29

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Published on: December 3, 2021

Triggering myocardial infarction by marijuana.

M A Mittleman1, R A Lewis, M Maclure

  • 1Institute for the Prevention of Cardiovascular Disease, Cardiovascular Division, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA. mmittlem@caregroup.harvard.edu

Circulation
|June 13, 2001
PubMed
Summary
This summary is machine-generated.

Marijuana smoking can trigger acute myocardial infarction, increasing risk significantly within an hour. This effect is rare but highlights potential cardiovascular risks associated with cannabis use.

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Area of Science:

  • Cardiology
  • Cannabis Research
  • Public Health

Background:

  • Increasing prevalence of marijuana use among individuals susceptible to coronary artery disease.
  • Known hemodynamic effects of marijuana smoking include increased heart rate and blood pressure fluctuations.
  • Uncertainty regarding marijuana's role in triggering myocardial infarction (MI).

Purpose of the Study:

  • To investigate whether marijuana use can precipitate acute myocardial infarction.
  • To quantify the risk of MI onset following marijuana consumption.

Main Methods:

  • Case-crossover study design involving 3882 patients with acute myocardial infarction.
  • Retrospective interviews conducted an average of 4 days post-MI.
  • Comparison of marijuana use in the hour preceding MI symptoms versus expected frequency.

Main Results:

  • 3.2% of MI patients reported marijuana use in the prior year; 9 used it within 1 hour of symptom onset.
  • Marijuana users were more likely to be male, current cigarette smokers, and obese.
  • A 4.8-fold increased risk of MI onset was observed within 60 minutes after marijuana use, rapidly diminishing thereafter.

Conclusions:

  • Marijuana smoking is identified as a rare trigger for acute myocardial infarction.
  • Further research into the mechanisms of marijuana-induced infarction may elucidate responses to other stressors.