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Protection against anthrax lethal toxin challenge by genetic immunization with a plasmid encoding the lethal factor

B M Price1, A L Liner, S Park

  • 1Department of Microbiology, The Ohio State University, Columbus, Ohio 43017-1292.

Infection and Immunity
|June 13, 2001
PubMed
Summary

Genetic vaccination using DNA plasmids encoding anthrax protective antigen (PA) or lethal factor (LF) protected mice against lethal toxin challenge. DNA immunization alone provides complete protection against anthrax toxin.

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