Rate of cognitive decline in AD is accelerated by the interleukin-1 alpha -889 *1 allele
G M Murphy1, J D Claassen, J J DeVoss
1Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, CA 94305, USA. gmurphy@leland.stanford.edu
Abstract:
The reason for differences in rate of cognitive decline in AD is unknown. The interleukin-1 alpha (IL-1 alpha) -889 *2 allele is associated with increased risk for AD. Surprisingly, in a sample of 114 patients followed for an average of 3.8 years, individuals homozygous for the IL-1 alpha -889 *1 allele declined significantly more rapidly on the Mini-Mental State Examination than did others. There was no difference in rate of decline between patients with and without the APOE epsilon 4 allele. These results support the hypothesis that inflammation is important in the clinical course of AD.
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