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Symptomatic HIV seroconverting illness is associated with more rapid neurological impairment
M R Wallace1, J A Nelson, J A McCutchan
1Naval Medical Center San Diego, CA, USA University of California at San Diego, CA, USA. mrwallace@nmscd.med.navy.mil
Objectives:
To establish whether symptomatic seroconverting illness in HIV infected people is associated with more rapid development of neurological impairment.
Methods:
166 HIV infected subjects with a known date of HIV infection enrolled in a longitudinal study of neurocognitive function were stratified by whether or not they had experienced a symptomatic serconverting illness.
Results:
29 of 166 (17.5%) dated HIV seroconverters had a history of symptomatic seroconverting illness. Though baseline neurocognitive function was similar, subjects with a symptomatic seroconverting illness developed clinical neurocognitive impairment significantly more rapidly than their asymptomatic counterparts in a survival analysis model (636 v 1075 days till impaired).
Conclusion:
Symptomatic seroconverting illness predisposes to more rapid neurocognitive impairment.