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[Association analysis of attempted suicide and 5-HT2A receptor gene]
1Department of Psychiatry, the First Affiliated Hospital, West China University of Medical Sciences, Chengdu, Sichuan 610041 P. R. China. caoliping@hotmail.com
Objective:
To examine the relationship of attempted suicide with A-1438G and T102C polymorphisms of 5-HT2A receptor gene.
Methods:
Genotypes and allele frequencies of A-1438G and T102C polymorphisms of 5-HT2A receptor gene in 149 attempted suicides and 190 normal controls were examined by polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP).
Results:
No differences in genotypes and allele frequencies of A-1438G and T102C polymorphisms of 5-HT2A receptor gene were observed between attempted suicides and the controls. However, an association between male attempted suicides and genotype(GG) of A-1438G polymorphism was found.
Conclusion:
These results suggested that liability to suicide behavior might be associated with A-1438G polymorpyhism of 5-HT2A receptor gene in male subjects.
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