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[Cyclin-dependent kinase 4 inhibitor a and tumor]
1Medical Genetics Department, the Second Military Medical University, Shanghai 200433 P. R. China. jlfu@guomai.sh.cn
Abstract:
INK4a/ARF locus encodes at least two products, P16(INK4a) and P19(ARF), which are very important in controlling cell-cycle arrest and apoptosis. Many human cancers have been found to be highly related to the mutations at this locus. Here is a review of its structure, function and role in tumor suppression.